Protein folding kinetics
Protein folding, the process by which proteins attain their functional 3-dimensional conformation is a fascinating problem. The geometry/topology of the proteins' native state can give novel information useful in finding a model for protein folding.
We use topology to analyze the 3-dimensional conformation of viral glycoproteins. Our results show that specific residues have a higher local conformational free energy, which could make them ideal targets for ligand binding and drug creation.